Topic: perilipin2 knockout mice

Dysregulated lipid homeostasis is a characteristic of brain aging and age-related neurodegenerative diseases. Perilipins, a family of proteins decorating the surface of lipid droplets (LDs), are key regulators of lipid metabolism in peripheral organs. Research indicates that the expression of perilipin2 increases in the brain with neurodegenerative diseases, such as Alzheimer’s disease, and preliminary data from our group suggest a reduced LD size in hippocampal neurons in response to the deletion of perilipin2. This project aims to investigate the connection between aging and the accumulation