Topic: peripheral metabolites

Due to its extremely finite energy reservoir, the brain is heavily reliant on blood-borne metabolites and their delivery through the blood-brain barrier to meet its regional and transient bursts of energetic needs. Despite this reliance, few studies investigating the controversial question of neuronal lactate use measure the contribution of peripheral metabolites. In this study, we investigated the impact of peripheral transporter inhibition on cortical extracellular metabolite fluctuations. The glucose (GLUT1; WZB117) and monocarboxylate (MCT1; AZD3965) transporter inhibitor, were administere