Temperature-sensitive transient receptor potential channels expressed in peripheral sensory neurons are functionally modulated by the tumor suppressor candidate 5
George Oprita, Dan Domocos, Vladimir Muzyka, Ana-Maria Taranciuc, Adelina Paduraru, Tudor Selescu, Alexandru Babes, Tudor Badea · FENS Forum 2024
Dorsal root ganglion (DRG) neurons are quintessential for peripheral pain transduction, a process mediated, among others, by certain members of the transient receptor potential (TRP) superfamily of ion channels. Among those, TRPA1, TRPV1, TRPM3 and TRPM8 have been linked to chronic pain and neuropathies. Tumor suppressor candidate 5 (Tusc5) plays a role in adipocyte function, but is also expressed in all major classes of DRG neurons. Tusc5 function in DRGs has not been investigated. We conducted Fura-2 calcium imaging and patch clamp experiments in cultured DRG neurons from knock-in Tusc5eGFP
ePoster · Neuroscience