Topic: peripubertal stress

Early life aversive experiences influence brain development, contributing to the emergence of psychiatric diseases, such as schizophrenia and major depression. Most of the inhibitory neurons in the thalamus are parvalbumin-expressing (PV+) cells located in the thalamic reticular nucleus (TRN). Alterations of PV+ interneurons, some of them mediated by perineuronal nets (PNNs), have been related to these psychiatric diseases. We have developed two models of early life aversive experiences on the TRN of adult mice. We have used a double-hit (DH) model in male mice combining an injection of the NM