Role of galanin receptor 2/3 in inflammation associated with peritonitis
Sara Huber, Stefanie Gaisbauer, Antonia Gantschnigg, Christina Brandstötter, Barbara Kofler · FENS Forum 2024
Peritonitis poses a serious medical challenge due to abdominal wall inflammation, often triggered by infectious agents. Understanding its immunological mechanisms is crucial for innovative therapies. The regulatory peptide galanin and its receptors (GAL1-3-R) are expressed on various immune cells and play pivotal roles in inflammation. The impact of GAL2/3-R knockout (KO) was assessed in a preclinical peritonitis model, using aged 4% thioglycollate medium (TGM) injected intraperitoneally in GAL2/3-R KO and corresponding WT mice. Comparison to vehicle controls was included to discern treatment-
ePoster · Neuroscience