Progesterone's neuroprotective effects in the prefrontal cortex of rats subjected to permanent bilateral common carotid artery occlusion
Ivana Guševac Stojanović, Milorad Dragić, Nikola Tatalović, Ana Todorović, Marina Zarić Kontić, Jelena Martinović, Nataša Mitrović, Zoran Stojanović, Ivana Grković, Duško Blagojević, Dunja Drakulić · FENS Forum 2024
Cerebral hypoperfusion (CH) is a contributing factor to impairments observed in individuals diagnosed with Alzheimer's disease, vascular dementia and the elderly population. CH-induced brain damage is closely associated with oxidative stress (OS), manifested through disturbed prooxidative/antioxidative balance (PAB) within cells. Elevated levels of xanthine oxidase (XOD) are identified as a potential causal factor of OS, ultimately culminating in cell death. We aimed to investigate the protective effects of the hormone progesterone (P4) against CH‐induced OS and neurodegenerative pathologies i
ePoster · Neuroscience