Memory matters: Cognitive decline in ischemic stroke and Alzheimer's disease
Robin Gens, Sylvie De Raedt, Engelborghs Sebastiaan, Ron Kooijman, Dimitri De Bundel · FENS Forum 2024
Ischemic stroke (IS) and Alzheimer's disease (AD) are debilitating neurological disorders marked by functional and cognitive deficits, sharing underlying pathological mechanisms. Recent research highlights the involvement of neurogenesis in both conditions, with alterations in neurogenesis linked to cognitive dysfunction. In our study, we aimed to investigate cognitive decline in a combined IS/AD model. To this end, IS was induced by permanent middle cerebral artery occlusion (pMCAO) in 4-months-old male and female 3xTg-AD vs wild-type (WT) mice. Our results revealed comparable sensorimotor re
ePoster · Neuroscience