Topic: persistent active MS neurons

Medial septal (MS) glutamatergic neurons expressing type 2 vesicular glutamate transporter (VGluT2) are active during theta oscillation and locomotor activity. Optogenetic activation of these neurons at theta frequencies (4-12 Hz) entrains hippocampal theta oscillation and sustains locomotion outlasting the stimulus duration. However, the specific cellular and circuit mechanisms responsible for initiating and sustaining MS VGluT2-driven persistent locomotion and associated hippocampal theta oscillations remain unclear. To address these questions, we optogenetically targeted glutamatergic neuro