Neuroanatomical basis for the anti-nociceptive role of the relaxin-3/RXFP3 peptidergic system
Thibault Dhellemmes, Marie Tuifua, Cynthia Alkhoury-Abboud, Rémi Kinet, Sandra Sánchez Sarasúa de la Bárcena, Margaux Lebouc, Jérémie Teillon, Mélina Petrel, André Calas, Eric Boué-Grabot, Akhter Hossain, Andrew Gundlach, Marc Landry · FENS Forum 2024
Affecting around 10% of world population, chronic pain and its related psychiatric comorbidities are major health issues. Implication of neuropeptides in modulation of pain remains poorly described in the brain. The relaxin-3 (RLN3) neuropeptide displays antidepressant and anxiolytic effects, and our preliminary results indicate an analgesic role in rodents. RLN3 is expressed by nucleus incertus (NI) neurons that project to different cortical (e.g. anterior cingulate cortex (ACC)) and subcortical (e.g. amygdala) areas of pain matrix.We aim at studying the pain modulatory effects of RLN3/RXFP3
ePoster · Neuroscience