Blunted TLR3-induced inflammatory gene expression in the prefrontal cortex of the valproic acid model of autism, an effect unaltered by increasing endocannabinoid tone
Jonathan Costello, Aofe M Thornton, David P Finn, Michelle Roche · FENS Forum 2024
Autism spectrum disorder (ASD) is associated with immune alterations and neuroinflammation. Increasing endocannabinoid tone attenuates ASD-related behavioural changes in rodent models and modulates Toll-like receptor (TLR)-induced neuro-immune responses. This study examined the effect of TLR3 activation, in the presence or absence of a fatty acid amide hydrolase (FAAH) inhibitor, on neuroinflammatory gene expression and endocannabinoid levels, in a preclinical rodent model of ASD. Female Sprague-Dawley rats prenatally exposed to either saline or valproic acid (VPA) received 1) the TLR3 agonist
ePoster · Neuroscience