ePoster · Neuroscience
Synthesis, molecular docking and motor function assessment of a novel diaryl pyrrole compound following the unilateral 6-hydroxydopamine lesion model in male rats
Elaheh HaghaniSamani, Anahita Torkaman-Boutorabi, Mona Salimi, Mohsen Amini, Araz Ghanbarpour · FENS Forum 2024
Aim: The intricate development of Parkinson's disease (PD) has posed a significant challenge in finding effective treatments. In the current study, a diaryl pyrrole compound, 1-(2-chlorophenyl)-2-methyl-5-(4-chlorophenyl)-1H-Pyrrole, was designed, synthesized, and tested for possible motor function improvement in 6-hydroxydopamine (6-OHDA) induced neurotoxicity in a rat model of PD.Method: Parkinsonism was triggered unilaterally by injecting 6-OHDA (12μg/4μl/rat) into the striatum. The compound (1,5,10 and 30 mg/kg) was then given intraperitoneally for 14 consecutive days following the 6-OHDA