PKC activators orchestrate neuronal immune modulation: Unveiling microglial dynamics in NF-kB activation and phagocytosis
Sofia Chanel Weinbender, Marco Zattoni, Bruno Benedetti, Moritz Brosch, Victor Lippert, Ariane Benedetti, Sabine Bernegger, Sébastien Couillard-Després, Ludwig Aigner · FENS Forum 2024
Chronic neuroinflammation, associated with central nervous system (CNS) pathologies, involves persistent microglial activation. Misfolded proteins in Alzheimer’s disease and mechanical CNS lesions initiate prolonged immune responses, contributing to neuronal damage. Recent literature suggests the induction of controlled immune modulation to foster neuro-restoration. We propose the use of protein kinase C (PKC) activators to modulate CNS innate immune cells (i.e., microglia) for regenerative therapeutic approaches. Therefore, we examined the molecular and functional effect of PKC activators (Pr