Nerve growth factor influences microglial activity via TrkA
Elea Coulomb, Giulia Borgonovo, Alexia Tiberi, Mariantonietta Calvello, Simona Capsoni, Antonino Cattaneo · FENS Forum 2024
The Nerve Growth Factor (NGF) has been linked to Alzheimer’s disease (AD) due to its survival-promoting activity on cholinergic neurons in the basal forebrain, whose demise contributes to cognitive decline in AD. Related to that, we demonstrated that intranasal administration of a painless NGF (hNGFp) displays a wide beneficial effect in the brain of an AD mouse model (5xFAD) by rescuing not only cholinergic defects, but also cortical and hippocampal beta-amyloid depositions and memory alterations. Since hNGFp only acts on Tropomyosin receptor kinase A (TrkA), and non-cholinergic neurons do no
ePoster · Neuroscience