Topic: pharmacological interventions

Study whether metabolic interventions can recruit oligodendrocyte-lineage cells for repair in progressive multiple sclerosis. The Blouet and Káradóttir laboratories combine demyelination models, pharmacological interventions, neuronal recordings, imaging and single-nucleus transcriptomics in a two-year translational research project.

Adult hippocampal neurogenesis is implicated in memory formation and mood regulation. The Thuret lab investigates environmental and molecular mechanisms controlling the production of these adult-born neurons and how they impact mental health. We study neurogenesis in healthy ageing as well as in the context of diseases such as Alzheimer’s and depression. By approaching neurogenesis in health and disease, the strategy is two folds: (i) Validating the neurogenic process as a target for prevention and pharmacological interventions. (ii) Developing neurogenesis as a biomarker of disease prediction