Topic: pharmacological signature

The eight metabotropic glutamate (mGlu1-8) receptors are key players in the modulation of the synaptic transmission. They have long been considered as homodimeric entities since they function only as mandatory dimers. However, it has been recently proposed that they can also heterodimerize in specific combinations, adding 16 new dimeric mGlu entities. This implied to characterize each heterodimer to develop tools to detect specifically their expression and activity in native tissues.The mGlu7 homodimers have a very low affinity for glutamate (mM) compared to that of the other mGlus (µM). It wa