Theta-locked fornix stimulation modulates the power and frequency of theta oscillations in the hippocampus
Brook Perry, Isaac Grennan, Anna Verghese, Melissa Jones, Oliver Harmson, Colin G McNamara, Robert Toth, Joram van Rheede, Andrew Sharott · FENS Forum 2024
High frequency deep brain stimulation of the fornix is currently being trialled as a treatment for the memory impairments associated with Alzheimer’s disease (AD), with mixed results. The fornix is a complex white matter bundle linking the hippocampal formation, basal forebrain and diencephalon. Clinicians have suggested that rather than delivering high frequency non-specific stimulation, broader efficacy might be achieved by selectively targeting the distinct neural activities present in the hippocampus, such as theta oscillations. Hippocampal theta oscillations have been strongly implicated