Topic: phasic inhibition

GABAergic neurotransmission generates two types of inhibitions: the transient activation of synaptic GABA receptors, or phasic inhibition, which elicits inhibitory postsynaptic currents, and the activation of extrasynaptic GABA receptors by “ambient” GABA which causes a persistent, “tonic”, inhibition that finely tunes cellular excitability of target neurons. Change in GABA synaptic efficacy is a crucial mechanism that underlies experience-dependent modifications of brain function. Several forms of GABA synaptic plasticity require retrograde signaling by endocannabinoids (eCB) through the acti