Topic: pheromonal pathway

The tumor protein p73 is involved in a variety of functions including neural development. p73-KO mice lack exploratory genital and mating behavior and are sterile. Since p73 is highly expressed in the vomeronasal organ (VNO), we examined centers related to the pheromonal pathway from embryonic day (E) 12 to adulthood, by using immunohistochemistry. In the p73 KO mouse, the VNO is smaller compared to the WT from the onset of development. However, the vomeronasal nerve (VNN) is present though reduced in size, and serves as a migration substrate for GnRH+ neurons from the olfactory placode to the