Topic: phospholipid scramblases

Neurons communicate through the formation of specialised junctions termed synapses, established by formation of extended protein networks. Our aim is to gain insights about the protein environment of the synapse by identification of novel proteins through employment of unbiased quantitative proteomic approaches. Here, we show results from a proteomic analysis of synaptic CAH10 protein complexes, which were affinity isolated from mouse brain. CAH10 was recently described as a pan-neurexin ligand. The interactome of CAH10 consists of presynaptic, secreted and post-synaptic proteins. Among them,