Topic: phosphorylated cAMP Response Element-Binding Protein (pCREB)

Exposure to novelty around the time of weak training enhances long-term memory (Ballarini et al., 2009). This enhancement is conserved across rodent models to humans (Fenker et al., 2009). It was proposed that synapses have been ‘tagged’ during the weak training and captured later by the strong event, i.e. novelty exposure (Moncada et al., 2007; Lisman et al., 2011). Concurrently, novelty induces dopamine and noradrenaline release in the hippocampus which similarly enhances memories (Moncada et al., 2011; Duszkiewicz et al., 2019). However, the synaptic and molecular changes induced by novelty