Topic: phosphorylated tau proteins

Alzheimer's disease (AD) develops undiagnosed for years. Diagnosis of AD remains relatively invasive and restricted to specialized centers calling for development of the new diagnostic markers. Retina may be an attractive source of such markers because it is an accessible part of the CNS (in vivo imaging and electrophysiology). Recent studies indicate pathological alterations in retina of AD patients such as retinal ganglion cell degeneration. Recently, we showed a dysfunction in the glutaminergic photoreceptor synapsis associated with a strong expression of phosphorylated tau proteins (p-tau)