Long-term implantation and cortical stimulation with photoactive organic semiconductors in a rat model
Marta Nowakowska, Marie Jakešová, Robert Reimer, Tony Schmidt, Ludovico Migliaccio, Julia Fuchs, Silke Patz, Vedran Đerek, Susanne Scheruebel, Theresa Rienmüller, Rainer Schindl, Eric Głowacki, Muammer Üçal · FENS Forum 2024
Neurostimulation employing photoactive organic semiconductors presents a promising alternative to conventional techniques, enabling targeted action and wireless control through light. This study investigates the efficacy of stimulation of the neuronal networks in vivo using organic electrolytic photocapacitors (OEPC) and explores the interactions between the device and neural tissue following a long-term implantation.OEPC implants were positioned subdurally on the somatosensory cortex of adult rats, with the craniectomy site sealed by a transparent window. Three weeks post-implantation, animal