Photopharmacological control of GABAergic neurotransmission
Galyna Malieieva, Karin Rustler, Alexandre Gomila, Matteo Ranucci, Ulrich Zeilhofer, Piotr Bregestovski, Burkhard Konig, Pau Gorostiza · FENS Forum 2024
Inhibitory neurotransmission in the brain is mainly mediated by GABAARs. Disequilibrium in their function leads to many sever neurological disorders, such as epilepsy, anxiety, depression. Thus, development of allosteric modulators that would regulate the activity of these receptors with minimized side effects is of great importance. Photopharmacology is a unique tool for these purposes allowing precise spatial and temporal light-driven control of pharmacophores´ activity, and consequently of their target proteins.Pursuing the goal to develop a GABAARs positive photomodulator, we successfully
ePoster · Neuroscience