Using photopharmacology as a tool to study mGlu5 hippocampal asymmetry in AD mice
Charleine Zussy, Mathieu Vitalis, Magalie Mathias, Anaëlle Dumazer, Xavier Gomez-Santacana, Cyril Goudet, Amadeù Llebaria, Laurent Givalois · FENS Forum 2024
The glutamatergic receptor mGlu5, being a modulator of neurotransmission in regions such as the cortex and hippocampus, plays a crucial role in learning and memory processing. Numerous studies highlight the alteration, contribution, and potential therapeutic targeting of mGlu5 in Alzheimer disease (AD). AD is the first cause of dementia, resulting in significant cognitive deficits, including memory loss due to the accumulation of Aβ, hyperphosphorylated tau, and neurodegeneration. In patients, brain asymmetric alterations, as Aβdepositions more pronounced in the left side, are reported early i
ePoster · Neuroscience