Topic: PIANP knockout mice

PIANP is a primarily neuronally localised protein which binds to the N-terminal domain of GABA-B receptors as well as the inhibitory immunoglobuline-like type 2 receptor PILRa [1]. In humans, a homozygous loss-of-function mutation of PIANP is associated with features of intellectual disability and global development delay whilst PIANP knockout mice display autism spectrum disorder (ASD)-like behaviour as well as heightened anxiety [2]. As we previously reported, PIANP knockout mice present with a different composition of telencephalic cell layers and increased neuronal apoptosis [2, 3]. Here,