Synergistic effects of α-synuclein, tau, and amyloid pathology on mitophagy in dementia with Lewy bodies
Wolfdieter Springer, Xu Hou, Tyrique Richardson, Fabienne Fiesel, Michael Heckman, Shunsuke Koga, Dennis Dickson · FENS Forum 2024
The kinase-ligase pair PINK1-PRKN recognizes and selectively labels worn-out and dysfunctional mitochondria with phosphorylated ubiquitin (pS65-Ub) to facilitate their elimination via autophagy (mitophagy). Although typically transient, pS65-Ub serves as a quantitative marker of mitochondrial damage but can also remain elevated due to insufficient degradation and flux through lysosomes. In human autopsy brain, the number of pS65-Ub positive cells increases with age but is also independently associated with Lewy body (LB), neurofibrillary tangles (NFT), and senile plaque (SP) burden. However, p
ePoster · Neuroscience