Unveiling the missing link between cell membrane signaling and mitochondria NCLX regulation: Crucial role of nitric oxide
Silvia Piccirillo, Tsipi Ben-Kasus Nissim, Ofir Avivi, Israel Sekler · FENS Forum 2024
Dynamic alterations in mitochondrial Ca2+ levels are recognized for their role in regulating both mitochondrial and cellular functions, as well as influencing energy metabolism (1). Recent studies reported that mitochondrial Na+/Ca2+ exchanger (NCLX) is regulated by PKA phosphorylation on its regulatory domain and PDE2 plays a crucial role as a physiological determinant in the PKA-mediated regulation of NCLX (2, 3). A major unsolved question is what links the cell membrane signaling to mitochondria NCLX regulation. Here, we fluorescently monitored [Ca2+]m efflux mediated by the NCLX in mice hi
ePoster · Neuroscience