Role of Protein Kinase N1 in cerebral energy metabolism and stroke
Stephanie zur Nedden, Motahareh Solina Safari, Dido Weber, Cyrille Orset, Thomas Freret, Haelewyn Benoît, Dragana Savic, Ira-Ida Skvortsova, Marcel Kwiatkowski, Madlen Hotzen, Sandro Carollo, Zlatko Trajanoski, Anne Krogsdam, Herbert Oberacher, Gabriele Baier-Bitterlich · FENS Forum 2024
We recently identified Protein kinase N1 (PKN1) as a negative regulator of neuronal AKT activity during postnatal cerebral development. Given the pivotal role of the AKT pro-survival signalling cascade in ischemia/reperfusion, our investigation aimed to determine whether PKN1-mediated AKT inhibition remains relevant during pathological conditions in the mature brain. Employing adult wild type and global Pkn1 knockout (Pkn1-/-) mice, we observed that Pkn1 knockout indeed imparts a protective phenotype in both, in vitro and in vivo stroke models. However, this was not associated with enhanced AK