Topic: placental CRH

Corticotropin-Releasing Hormone (CRH) was first identified as a neurohormone secreted by the hypothalamus in response to stressful stimuli. However, large amounts of CRH are also secreted by the placenta of anthropoid primates during pregnancy. Although the role of hypothalamic CRH has been extensively studied, there is a remarkable lack of evidence regarding the role of placental CRH, while the biological significance of its unique expression pattern in anthropoid primates remains elusive. In order to investigate the effects of placental CRH on human brain development and to overcome the limi