Plasticity in iPSC-derived 2D cortical neuronal networks
David Jenkins, Adele Ludlam, Eric Hill, Rhein Parri · FENS Forum 2024
As part of the NeuChiP project aimed at developing Biological AI, we aimed to establish the plasticity properties of human-induced pluripotent stem cell (hiPSC) derived cortical networks. Objectives were to establish capacity and characteristics of human cultured networks.To achieve this, we engineered mouse cortical cultures and hiPSC-derived cortical neural networks into mature, specific configurations. Functional assessments were conducted with fluorescence calcium imaging and planar HD-MEA electrophysiological recording (3Brain - Duplex system).iPSC derived neural cultures were plated on c
ePoster · Neuroscience