Receptor Protein Tyrosine Phosphatase β/ζ regulates high-fat diet-induced deleterious cognitive effects and Aβ plaque formation in APP/PS1 mice
Teresa Fontán-Baselga, Héctor Cañeque-Rufo, Elisa Rivera-Illades, Esther Gramage, José María Zapico, Beatriz de Pascual-Teresa, Gonzalo Herradón, Marta Vicente-Rodríguez · FENS Forum 2024
Obesity is linked to neurodegenerative diseases through neuroinflammation. Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders of diverse origin. PTN is a ligand and an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. To investigate the role of RPTP β/ζ, in neuroinflammation and neurodegeneration, we used the APP/PS1 genetic model of Alzheimer disease (AD) and a high-fat diet (HFD)-induced obesity model. Three-month-old wild type (WT) mice were fed with standard chow or HFD (60 Kcal % fat) for three months. MY10, an exogenous R
ePoster · Neuroscience