Pleiotrophin: A bridge between obesity and neurodegenerative disorders promoting memory loss and glial alterations by modulating neuroinflammation and perineuronal nets
Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón · FENS Forum 2024
Obesity and metabolic disorders are linked with neurodegenerative diseases through persistent peripheral inflammation caused by metabolic alterations, which underlies chronic neuroinflammation. Pleiotrophin (PTN) is a cytokine that regulates neuroinflammation and metabolism in different contexts. Thus, our study aimed to determine the role of PTN in the brain-periphery crosstalk in a high-fat diet (HFD)-induced obesity model. Three-month-old C57BL/6J wild-type (Ptn+/+) and Ptn genetically deficient (Ptn−/−) mice were fed with standard chow diet or HFD (60% kcal fat) for 6 months. HFD-Ptn−/− mi
ePoster · Neuroscience