Polymeric nanoparticles as drug delivery tools for brain degenerative disorders: In vitro assessment and drug release properties
Rebecca Maher, Almudena Moreno Borrallo, Eduardo Ruiz-Hernandez, Andrew Harkin · FENS Forum 2024
Therapies for neurodegenerative disease are limited in efficacy and tolerability, largely due to poor drug penetration across the BBB and off-target effects. Polymeric nanoparticles (NPs) are advantageous for brain drug delivery due to their safety profiles, drug-loading capacity, controlled-release properties and potential for drug repurposing. The aim of this work was to perform in vitro screening of NPs synthesised using the FDA-approved poly(lactic co-glycolic acid) (PLGA) polymer as drug delivery vehicles in primary rat neurons and glia as a prerequisite for further assessment in animal m
ePoster · Neuroscience