Chemogenetic activation of oligodendrocytes modulates behavioural processes
Stefano Calovi, Carla Peiró, Alba Legarda, Maria Villafranca-Faus, Pablo Reyes-Velazquez, Edgar Soria-Gomez, Maria Domercq · FENS Forum 2024
Experience and neuronal activity can induce dynamic changes in myelination during development and in adult life, suggesting a new form of plasticity to adapt brain function to environmental stimuli. Myelin remodeling is driven mainly by newly-formed oligodendrocytes from precursors cells. However, the role of mature oligodendrocytes in plastic changes of myelin is less known. In order to analyze the role of mature oligodendrocytes, we have used inducible transgenic mice expressing the DREADD receptor hM3Dq in PLP+ myelinating cells. In vivo chronic CNO treatment shortened the nodes of Ranvier
ePoster · Neuroscience