Increased Semaphorin 3A expression levels affect axonal elongation and dendritic architecture in human neural progenitors during the early stages of differentiation
Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier, Carmela Matrone · FENS Forum 2024
Semaphorin 3A (SEMA3A) is a repellent guidance cue considered instrumental in many processes that shape the nervous system during development. It is produced as a secreted protein in mammals and exerts both autocrine and paracrine functions. Interestingly, emerging evidence highlights the association of genetic and functional alterations in SEMA3A or its receptors (NRP1 and PLXNA2) with neurodevelopmental disorders. Indeed, increased SEMA3A expression levels have been detected in the brains of patients with schizophrenia, and several mutations in the SEMA3A, NRP1, or PLXNA2 genes have been des
ePoster · Neuroscience