Topic: PME genes

Progressive myoclonus epilepsies (PMEs) represent a group of epilepsy disorders that begin in adolescence and are inherited in an autosomal recessive manner. PME patients exhibit a range of symptoms, including seizures, ataxia, muscle atrophy, dementia, psychosis, and hallucinations. The majority of these subsequent symptoms are likewise observed in older individuals, indicating the potential involvement of the PME genes in the process of aging. A recent study conducted by our group has shown that the expression of PME genes shows an inverse association with age in the normal brain. Since the