Topic: pMN domain

In the central nervous system (CNS), the formation of functional neuronal networks during development depends on the ability of neuroepithelial progenitor (NEPs) to generate neurons and glial cells – oligodendrocytes and astrocytes - in a highly specific manner, both temporally and spatially. In the ventral neural tube, depending on both its concentration and timing of exposure, Sonic Hedgehog (Shh) - released by the notochord and floor plate cells - regulates expression of transcription factors that demarcate distinct NEP domains dedicated to sequentially generate specific neuronal and glial