Determining the role of enhanced perineuronal net deposition in seizure susceptibility in Angelman syndrome model mice
Abd Alrahman Elaksher, Ben Philpot, Mason Riley · FENS Forum 2024
Neurological disorders can be caused by genetic alterations in many genes; UBE3A is one such gene, as a mutation or deletion in the maternal copy of this gene has been shown to cause Angelman Syndrome (AS). AS is a developmental disorder that affects 1 in 15,000 live births, and is characterized by many symptoms, with seizures being highly penetrant and debilitating. Previous research on the pathological characterization of AS model mice showed an increased seizure susceptibility as well as abnormally high levels of perineuronal net (PNN) fluorescence. Our project aims to determine whether the
ePoster · Neuroscience