Topic: Pogz+/-

Male predominance is one of the least understood characteristics of Autism Spectrum Disorder (ASD). While more than a hundred genes are involved in ASD, only a few of them show sex differences in behavior. In a previous work, we found that male mice harboring a mutation in the Pogz gene (Pogz+/-) show sexually dimorphic overly friendly behavior in several sociability assays. Mapping the engaged neurons during social recognition revealed that in Pogz+/- males, there are more activated neurons in the basolateral amygdala (BLA) than control and Pogz+/- female mice. To characterize the morphophysi