O2L-001, an innovative thrombolytic to evacuate intracerebral haematoma
Audrey Thiebaut, Estelle Louet, Mélina Ianszen, Marie-Julie Guichard, Daniel Hanley, Christophe Gaudin, Jerome Parcq · FENS Forum 2024
Intracerebral haemorrhage (ICH) is an unmet medical need leading to the formation of an intracerebral haematoma. Updated guidelines for the management of ICH patients recognize that minimally invasive approaches for evacuation of hematoma open a new area for treatment. Here we demonstrated that O2L-001 allowing the extended-release of a new rtPA variant named OptPA, offers an improved efficacy for haematoma evacuation as well as the best safety.OptPA was produced in CHO cell line before purification, nanoprecipitation using the NANOp2Lysis® technological platform followed by suspension in a so
ePoster · Neuroscience