Topic: Poly I:C model

The mammalian brain is an extremely complex structure, based on the equilibrium betweenexcitatory and inhibitory neurons. In the rodent thalamus, GABAergic interneurons are locatedalmost exclusively in the thalamic reticular nucleus (TRN), where they regulate the excitation of the rest of thalamic nuclei, such as the Ventral Posterolateral (VPL) andMediodorsal (MD). Many of these interneurons express parvalbumin (PV), a calcium bindingprotein, and their somata and proximal dendrites are surrounded by a specialized region ofextracellular matrix, the perineuronal nets (PNNs). Recent studies have