Topic: Poly I:C mouse model

Schizophrenia has been long thought to be a mainly neurodevelopmental disease, but current research increasingly highlights the involvement of autoimmunological and inflammatory processes. Recently, the gut-brain axis has become the focus of research as various components of this axis appear to be altered in psychiatric illnesses including schizophrenia. Schizophrenic patients not only show reduced diversity in their microbiome compared to healthy controls, but also several parameters of elevated peripheral and central inflammation. The Poly I:C mouse model is based on epidemiological findings