Topic: polyamines

Although essential for protein structure, stability and function, polyamination is still poorly explored posttranslational modification. In the brain, polyamines (putrescine, spermidine and spermine), are involved in a variety of neuronal processes, including neuronal development, neurotransmission, neuroprotection and synaptic plasticity, but it remains to be identified what is the role of polyamination in these mechanisms.Hippocampal pyramidal neurons exhibit specific properties, depending on the subregion. Those found in the subregion CA1 possess plastic synapses and are very sensitive to e