Topic: polysynaptic inhibition

The striatum is the predominant input structure of the striatum, receiving converging glutamatergic and GABAergic inputs from cortical and subcortical regions. It also receives modulatory input from midbrain dopamine neurons which has been shown to be critical for motor initiation, learning and reward. Additionally, the striatum also receives serotonergic input with one third of serotonergic neurons projecting from the dorsal raphe nucleus (DRN) to the striatum. Here, we studied the impact of 5-HT on the interactions between Cholinergic interneurons (ChINs). ChINs are key modulators of striata