Modulation of mouse hippocampal lipidomic signature by FTY720, a sphingosine-1-phosphate analogue used for treating relapsing-remitting multiple sclerosis
Daniela Magalhães, Nicolas A. Stewart, Myrthe Mampay, Sarah O. Rolle, Chloe Hall, Emad Moeendarbary, Melanie S. Flint, Ana M. Sebastião, Claudia A. Valente, Marcus K. Dymond, Graham K. Sheridan · FENS Forum 2024
FTY720 (fingolimod), a synthetic sphingosine 1-phosphate (S1P) analogue, is a drug employed for treating relapsing-remitting multiple sclerosis in diverse age groups. With the ability to cross the blood-brain barrier, FTY720 gradually accumulates within lipid-rich areas of the central nervous system (CNS) by integrating into phospholipid membranes. Consequently, FTY720 can enhance cell membrane fluidity, influencing glial cells and neuronal populations involved in behaviour regulation. This study investigated the impact of chronic FTY720 administration (3.3 μg/ml in ad libitum drinking water f
ePoster · Neuroscience