Movement coordination via a cortico-ponto-thalamic loop
Emília Bősz, Viktor M. Plattner, Laszlo Biró, Kata Kóta, Marco A. Diana, Laszlo Acsady · FENS Forum 2024
Highly specialized subcortical motor networks govern movement and locomotion. The cortico-basal ganglia (BG)-thalamocortical loop is crucial for movement control, and disruption of BG activity leads to unilateral rotation.We investigated whether the pontine reticular formation (PRF) also participates in a motor-related, cortico-subcortico-thalamocortical loop since PRF sends inhibitory terminals to the intralaminar thalamic nuclei (IL) and parafascicular nucleus (Pf), like BG, both in rodents and humans. We studied the effects of unilateral optogenetic activation of PRF inhibitory cells (PRF/G
ePoster · Neuroscience