CD200-based cell sorting generates homogeneous subpopulations of transplantable striatal neuroblasts
Cinta Gomis, F. J. Molina-Ruiz, P. Sanders, J. Abante, F. Londoño, G. Bombau, M. Galofré, V. Monforte, O. Varea, J. M. Canals · FENS Forum 2024
Cell replacement therapy (CRT) holds promise for restoring atrophied tissue in Huntington’s Disease (HD) by replenishing degenerating striatal projection neurons (SPNs). However, the heterogeneous cell compositions resulting from striatal differentiation protocols hinder clinical translation. Standardizing production procedures is essential to ensure the generation of defined and safe cell products. This study aims to devise a novel therapeutic approach for brain tissue regeneration in HD, ensuring the presence of specified SPN progenitors while excluding overly proliferative cell types.Here,
ePoster · Neuroscience