Nicotinamide supplementation mitigates synaptic plasticity impairment and cognitive decline after tibial fracture surgery in aging mice
Tatiana Guncay, Jorge Concha-Cerda, Pamela Contreras, J. Brañes, Daniela P Ponce, Jamileth More, Genaro Barrientos, Cecilia Hidalgo, Felipe Salech · FENS Forum 2024
Post-operative delirium (POD) in elderly patients is associated with increased cognitive decline, morbidity, and mortality. Neuroinflammation and NAD+ imbalance contribute to POD. We investigated the imbalance of NAD+-consuming enzymes, particularly sirtuins and CD38, associated with neuroinflammation. Additionally, we examined Nicotinamide (NAM), a precursor of NAD+, for its potential to alleviate neuroinflammation and metabolic imbalance.Female C57BL/6J mice aged 20-22 months underwent tibial fracture surgery and received pre- and post-surgery NAM treatment. Neuroinflammation, synaptic plast
ePoster · Neuroscience