Investigating the impact of seizure-associated spreading depolarisation to postictal depression and loss of arousal in a novel model of temporal lobe epilepsy
Neela Codadu, Eduard Masvidal-Codina, Enrique Fernández-Serra, Randy Gyimah, Hasna Boumenar, Yunan Gao, Anton Guimera-Brunet, Rob Wykes · FENS Forum 2024
Generalised and focal to bilateral convulsive seizures are risk factors for Sudden Unexpected Death in Epilepsy (SUDEP). Postictal generalized EEG suppression (PGES), a generalized flattening of the scalp EEG, is a potential marker of increased seizure severity and risk of SUDEP. PGES has been variably linked to autonomic dysfunctions including loss of arousal. Risk of SUDEP may be increased in direct proportion to duration of PGES and loss of arousal. Convulsive seizures can co-exist with spreading depolarisation (SD), a slowly propagating wave of neuronal and glial depolarisation (typically
ePoster · Neuroscience