Topic: posttranslational protein modifications

The extracellular matrix protein reelin, named after the reeler-mutant mouse, exerts a multitude of key functions in both the developing and adult brains of mammals. In addition to the well-studied effect of reelin on the migration of neuronal cells during embryonic development, several studies have demonstrated an effect of reelin on neuronal signaling in the mature brain. By modulating both excitatory glutamatergic and inhibitory GABAergic neuronal signaling, reelin affects central neurophysiological processes such as learning and memory formation. We aim to further investigate reelin-induce